High tumor mutation burden indicates a poor prognosis in patients with intrahepatic cholangiocarcinoma

Table 2 Grouping analysis of the relationship between tumor mutation burden and overall survival

	Median survival (mo)		Log-rank test
	TMB-high	TMB-low	HR	P value
Tumor grade
Well differentiated	- (n = 5)	56.1 (n = 10)	0.64 (0.15-2.27)	0.582
Moderately differentiated	26.5 (n = 79)	42.5 (n = 134)	1.46 (1.02-2.08)	0.026
Poorly differentiated	20.2 (n = 52)	29.8 (n = 82)	1.72 (1.11-2.66)	0.007
Disease progression
Solitary liver tumor	55.1 (n = 44)	69.4 (n = 93)	1.42 (0.85-2.38)	0.140
Multifocal liver disease	24.4 (n = 31)	40.6 (n = 46)	1.85 (1.00-3.43)	0.026
Metastatic disease	15.5 (n = 65)	15.8 (n = 100)	1.17 (0.83-1.66)	0.357
Tumor resection
Resected	36.6 (n = 67)	61.5 (n = 127)	1.77 (1.17-2.66)	0.002
Unresected	17.5 (n = 73)	17.7 (n = 112)	1.13 (0.81-1.59)	0.461

TMB: Tumor mutation burden.