High tumor mutation burden indicates a poor prognosis in patients with intrahepatic cholangiocarcinoma

Table 1 Clinical characteristics of the study population

Characteristics	All patients (n = 412)
	Number (n)	Percent (%)
Age, yr
Median	63
Range	18-88
< 65	188	45.6
≥ 65	224	54.4
Gender
Female	190	46.1
Male	222	53.9
BMI
Median	27.5
Range	17.6-59.8
< 28	191	46.4
≥ 28	217	52.7
TMB, mut/Mb
Median	2.5
Range	0-51.6
≤ 3.1	239	58.0
> 3.1	140	34.0
CA19-9
< 40 U/mL	121	29.4
≥ 40 U/mL	192	46.6
Chronic viral hepatitis
Negative	379	92.0
Positive	33	8.0
Tumor resection
Resected	203	49.3
Unresected	209	50.7
Tumor grade
Well differentiated	15	3.6
Moderately differentiated	231	56.1
Poorly differentiated	146	35.4
Disease progression
Solitary liver tumor	148	35.9
Multifocal liver disease	86	20.9
Metastatic disease	178	43.2
Smoking status
Never smoked	202	49.0
Former smoker	166	40.3
Current smoker	41	10.0

BMI: Body mass index; TMB: Tumor mutation burden.