Development and validation of a prognostic nomogram for decompensated liver cirrhosis

Table 2 Univariate and multivariate Cox regression analyses in decompensated liver cirrhosis patients from the derivation cohort (n = 329)

	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age	1.021 (1.001-1.040)	0.037a	1.028 (1.007-1.050)	0.009a
Male sex	1.133 (0.653-1.967)	0.657
Vasopressors
No	Reference
Yes	1.643 (1.027-2.628)	0.038a
HBeAg
negative	Reference
positive	0.692 (0.301-1.594)	0.387
Mechanical ventilation
No	Reference
Yes	9.916 (5.486-17.922)	< 0.001a	4.200 (1.975-8.932)	< 0.001a
ALT	1.001 (1.000-1.002)	< 0.001a
AST	1.001 (1.000-1.001)	< 0.001a
GGT	1.001 (1.000-1.002)	0.090a
ALP	1.002 (1.001-1.003)	< 0.001a
Serum sodium	1.003 (0.982-1.026)	0.761
WBC	1.052 (1.030-1.073)	< 0.001a
Platelet	1.002 (0.999-1.004)	0.259
MAP	0.976 (0.967-0.996)	0.019a	0.979 (0.960-0.998)	0.031a
PO2/FiO2	0.996 (0.994-0.998)	< 0.001a	0.998 (0.995-1.000)	0.038a
CTP score	1.332 (1.214-1.462)	< 0.001a
MELD score	1.142 (1.107-1.178)	< 0.001a	1.080 (1.030-1.132)	0.002a

^aSignificant P value.

HBeAg: Hepatitis Be antigen; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transferase; ALP: Alkaline phosphatase; WBC: White blood cell; MAP: Mean arterial blood pressure; PO₂/FiO₂: Arterial oxygen partial pressure/inhaled oxygen concentration; CTP score: Child-Turcotte-Pugh score; MELD score: Model for end-stage liver disease score.