Evaluation of high-risk factors and the diagnostic value of alpha-fetoprotein in the stratification of primary liver cancer

Table 8 Evaluation of four indicators for diagnosing small liver cancer alone and in combination

Diagnostic indicators	AUC	Sensitivity, %	Specificity, %	Std.Error	95%CI	Z	P value
AFP	0.595	38.64	84.68	0.0519	(0.552, 0.632)	1.93	0.067
CEA	0.649	52.27	75.22	0.0461	(0.589, 0.706)	3.23	0.0013
CA-199	0.719	81.82	66.18	0.0467	(0.671, 0.763)	4.69	< 0.0001
GGT	0.728	77.27	56.89	0.0390	(0.671, 0.780)	5.84	< 0.0001
Combined diagnosis	0.810	68.18	79.56	0.0349	(0.758, 0.855)	8.90	< 0.0001

AUC: Area under the curve; AFP: Alpha-fetoprotein; CEA: Carcinoembryonic antigen; CA 19-9: Carbohydrate antigen 19-9; GGT: Gamma-glutamyl transferase.