Early diagnostic value of liver stiffness measurement in hepatic sinusoidal obstruction syndrome induced by hematopoietic stem cell transplantation

Table 3 Liver stiffness measurement allows early diagnosis of veno-occlusive disease/sinusoidal obstruction syndrome in patients who undergo hematopoietic stem cell transplantation

Country	Year	Study design	Age	HSCT patients (n)	SOS patients (n)	LSM method	LSM (baseline)	LSM (peak)	AUC	Sensitivity	Specificity	Ref.
Italy	2019	Prospective	Adult	78	4	FibroScan	3.7-8.8	15-34.3	0.997	75%	98.70%	Colecchia et al[86]
Italy	2016	Retrospective	Children	22	4	FibroScan	4-6	12-20				Colecchia et al[87]
Italy	2022	Prospective	Adult	21	2	FibroScan	6.7	> 21 kPa				Ravaioli et al[85]
Turkey	2022	Prospective	61 yr, 65 yr	31	2	FibroScan	8.2	55, 17.7	0.569	100%	55.17%	Özkan et al[92]
United States	2017	Prospective	Adult	25	5	SWE	0.02 ± 0.18 m/s	0.25 ± 0.21 m/s	0.7762	80%	67%	Reddivalla et al[84]
France	2021	Retrospective	Adult	146	6	2D-SWE		> 8.1 kPa	0.84	75%	99%	Debureauxet al[93]
Spain	2011	Retrospective	Adult		2	ARFI		2.75 m/s, 2.58 m/s				Fontanilla et al[79]
Italy	2019	Retrospective	Children	-	3	FibroScan	2.8-4.6	34.3-36	-	-	-	Zama et al[94]

AUC: Area under the curve; 2D-SWE: Two-dimensional-shear wave elastography; ARFI: Acoustic radiation force impulse; HSCT: Hematopoietic stem cell transplantation; SOS: Sinusoidal obstruction syndrome; LSM: Liver stiffness measurement.