Pyroptosis-related genes play a significant role in the prognosis of gastric cancer

Figure 4 Construction of risk signature in The Cancer Genome Atlas cohort. A: Univariate Cox regression analysis of overall survival (OS) for each pyroptosis-related genes, and 23 genes with P < 0.001; B and C: The results of the least absolute contraction and selection operator (LASSO) Cox regression indicated that there were 11 OS-related genes; D: Distribution of patients based on the median value of risk score; E and F: Principal component analysis (PCA) plot and t-distributed stochastic neighbor embedding (t-SNE) analysis founded on the risk score; G: The distributions of OS status, OS and risk score for each patient; H: Kaplan-Meier curves for the OS of patients in the high-risk and low-risk groups; I: Area under the curve (AUC) of time-dependent receiver operating characteristic (ROC) curves demonstrated the sensitivity and specificity of the risk score.