Short- (30-90 days) and mid-term (1-3 years) outcomes and prognostic factors of patients with esophageal cancer undergoing surgical treatments

Table 4 Univariable and multivariable Cox regression analyses of overall survival

	Univariable			Multivariable
	HR	95%CI	P	HR	95%CI	P
Age	1.018	0.979, 1.059	0.377
Sex
Female	ref
Male	1.020	0.58, 1.796	0.945
Body mass index
< 28	ref
≥ 28	1.912	0.816, 4.478	0.136
Smoking	1.185	0.663, 2.118	0.567
Drinking	0.916	0.285, 2.942	0.882
Family history of esophagus cancer	1.372	0.545, 3.452	0.501
Hypertension	0.939	0.530, 1.663	0.829
Diabetes	1.898	0.810, 4.449	0.140
Hemoglobin	0.987	0.971, 1.004	0.125
D-dimer	1.000	0.999, 1.001	0.782
Albumin	1.004	0.945, 1.067	0.897
Creatinine	1.020	1.003, 1.036	0.020	1.016	1, 1.032	0.050
Tumor diameter	1.244	1.083, 1.429	0.002
T stage
Tis/0-2	ref			ref
3-4	2.327	1.331, 4.068	0.003	1.869	0.98, 3.564	0.058
N stage
0	ref
1-3	2.869	1.659, 4.962	< 0.001
G stage
< 2	ref
≥ 2	1.990	1.062, 3.73	0.032
pTNM stage
0/I/II	ref			ref
III/IVA	4.117	2.349, 7.213	< 0.001	4.189	2.190, 8.012	< 0.001
Pathological type
Squamous cell carcinoma	ref
Others	0.616	0.222, 1.711	0.353
Received preoperative radiotherapy or chemotherapy	1.157	0.592, 2.261	0.669
Operation method
ESD/endoscopy/thoracoscopy/laparoscopy	ref
Thoracotomy/laparotomy	0.867	0.312, 2.405	0.784
Lymph node dissection	3.622	0.500, 26.255	0.203
Postoperative radiotherapy and/ or chemotherapy	0.449	0.225, 0.897	0.023	0.234	0.112, 0.488	< 0.001
Number of metastatic lymph nodes	1.277	1.109, 1.471	0.001
CCI	1.029	1.014, 1.044	< 0.001	1.018	1.004, 1.032	0.011

HR: hazard ratio; CI: confidence interval; ESD: Endoscopic submucosal dissection; CCI: Comprehensive Complication Index.