Intestinal mucosal barrier in functional constipation: Dose it change?

Figure 3 Immunohistochemical analysis of occludin and zonula occludens-1 expression in healthy controls and patients with functional constipation. A: Colonic mucosal occludin expression in healthy controls (Scale bar = 20 μm); B: Colonic mucosal occludin expression in functional constipation (FC) patients (Scale bar = 20 μm); C: Colonic mucosal zonula occludens-1 (ZO-1) expression in healthy controls (Scale bar = 20 μm); D: Colonic mucosal ZO-1 expression in FC patients (Scale bar = 20 μm); E and F: No significant differences in occludin or ZO-1 expression were found between healthy controls and FC patients (P = 0.240 and P = 0.333, respectively). FC: Functional constipation; ZO-1: Zonula occludens-1; MOD: Mean optical density.