Identification of potential key molecules and signaling pathways for psoriasis based on weighted gene co-expression network analysis

Table 3 Kyoto Encyclopedia of Genes and Genomics function enrichment of differentially expressed mRNAs

Category	hsa	Term	Count	P value	Genes
KEGG_PATHWAY	hsa03320	PPAR signaling pathway	14	3.07E-06	GK, MMP1, ADIPOQ, LPL, FADS2, ACADL, ACOX2, FABP5, FABP7, ACSBG1, PLIN1, ANGPTL4, SLC27A4, PPARD
KEGG_PATHWAY	hsa05164	Influenza A	22	1.05E-05	NLRX1, RSAD2, DDX58, STAT1, TMPRSS4, MX1, MAPK13, PYCARD, CXCL10, SOCS3, OAS1, OAS2, IL-1B, OAS3, TNFSF10, IRF7, CCL2, PRSS3, KPNA2, PRSS2, MYD88, IRF9
KEGG_PATHWAY	hsa05133	Pertussis	12	2.56E-04	PYCARD, C1QB, CASP7, NOS2, CALML5, IL-1B, IRF1, IRF8, CALML3, FOS, MYD88, MAPK13
KEGG_PATHWAY	hsa05162	Measles	16	4.14E-04	DDX58, STAT1, MX1, CD3G, CD3D, OAS1, CCNE2, CCNE1, OAS2, IL-1B, OAS3, TNFSF10, IRF7, PRKCQ, MYD88, IRF9
KEGG_PATHWAY	hsa04668	TNF signaling pathway	14	4.87E-04	MLKL, CCL20, CXCL1, FOS, NOD2, SELE, MMP9, MAPK13, CXCL10, SOCS3, CASP7, IL-1B, CCL2, JUNB
KEGG_PATHWAY	hsa04062	Chemokine signaling pathway	19	7.44E-04	LYN, CXCL9, CCL22, STAT1, CCL20, CXCR4, CXCL1, CXCL13, CXCL10, HCK, CCL8, PLCB4, CXCR2, RAC2, CCL2, CCR7, CCL19, CCL18, CCL27
KEGG_PATHWAY	hsa04060	Cytokine-cytokine receptor interaction	21	0.002838	CXCL9, IL20, IL4R, CCL22, CCL20, CXCR4, IL19, CXCL1, CXCL13, CXCL10, CCL8, IL-1B, CXCR2, TNFSF10, CCL2, CCR7, CCL19, IL7R, CCL18, CCL27, TNFRSF21
KEGG_PATHWAY	hsa05160	Hepatitis C	14	0.003635	DDX58, STAT1, IFIT1, CLDN1, MAPK13, SOCS3, OAS1, OAS2, IRF1, OAS3, CLDN8, IRF7, CLDN17, IRF9
KEGG_PATHWAY	hsa00590	Arachidonic acid metabolism	9	0.003655	PLA2G2F, HPGDS, GPX2, PLA2G4D, PLA2G2A, PLA2G3, ALOX12B, CYP2E1, CYP4F8
KEGG_PATHWAY	hsa04110	Cell cycle	13	0.00555	BUB1B, TTK, CDC6, CDC25B, CCNA2, CDC20, CCNB2, CCNB1, CCNE2, PTTG1, CCNE1, CDK1, MAD2L1
KEGG_PATHWAY	hsa05142	Chagas disease (American trypanosomiasis)	11	0.011418	C1QB, GNA15, PLCB4, NOS2, IL-1B, CCL2, CD3G, FOS, CD3D, MYD88, MAPK13
KEGG_PATHWAY	hsa04114	Oocyte meiosis	11	0.017478	CDC20, CCNB2, CCNB1, PTTG1, CALML5, CCNE2, CCNE1, CDK1, CALML3, MAD2L1, AURKA
KEGG_PATHWAY	hsa00592	Alpha-Linolenic acid metabolism	5	0.018996	PLA2G2F, FADS2, PLA2G4D, PLA2G2A, PLA2G3
KEGG_PATHWAY	hsa05168	Herpes simplex infection	15	0.020979	DDX58, STAT1, TAP1, FOS, IFIT1, SOCS3, OAS1, OAS2, IL-1B, OAS3, IRF7, CDK1, CCL2, MYD88, IRF9
KEGG_PATHWAY	hsa04380	Osteoclast differentiation	12	0.021031	FOSL1, SOCS3, FCGR3B, STAT1, LCK, IL-1B, BLNK, ACP5, FOS, JUNB, IRF9, MAPK13
KEGG_PATHWAY	hsa04064	NF-kappa B signaling pathway	9	0.028614	LYN, BCL2A1, DDX58, LCK, IL-1B, BLNK, PRKCQ, CCL19, MYD88
KEGG_PATHWAY	hsa04621	NOD-like receptor signaling pathway	7	0.028679	PYCARD, IL-1B, CARD6, CCL2, CXCL1, NOD2, MAPK13
KEGG_PATHWAY	hsa00591	Linoleic acid metabolism	5	0.031316	PLA2G2F, PLA2G4D, PLA2G2A, PLA2G3, CYP2E1
KEGG_PATHWAY	hsa00120	Primary bile acid biosynthesis	4	0.031945	CYP39A1, CH25H, ACOX2, CYP7B1
KEGG_PATHWAY	hsa00140	Steroid hormone biosynthesis	7	0.033377	SULT2B1, HSD11B1, STS, HSD3B1, HSD17B2, CYP2E1, CYP7B1
KEGG_PATHWAY	hsa01100	Metabolic pathways	64	0.037857	ST6GALNAC1, GDA, GLDC, PIK3C2G, PYGL, HK2, SMPD3, IL4I1, HPGDS, PNP, ACADL, SPTLC2, KYNU, NAMPT, LIPG, HYAL4, PGM2, TK1, UPP1, AASS, PLA2G4D, ARG1, GPT2, AMPD3, NME1, ALDH3A1, PLCB4, ACOX2, CMPK2, ACSBG1, CYP2E1, IDO1, PLA2G3, ALOX12B, FUT2, CYP2C18, FUT1, FUT3, TYMP, HSD11B1, UGCG, RDH12, HSD17B2, RDH16, ATP6V0A4, XDH, HAO2, PLA2G2F, GALNT6, RRM2, GK, GCH1, NOS2, PLA2G2A, HSD3B1, CYP4F8, ALDH4A1, SQLE, HAL, AKR1B10, DHRS9, POLE2, POLR3G, HPSE
KEGG_PATHWAY	hsa05143	African trypanosomiasis	5	0.047416	PLCB4, IL-1B, SELE, MYD88, IDO1