Transition from minimal change disease to focal segmental glomerulosclerosis related to occupational exposure: A case report

Figure 2 Light microscopy and electron microscopy of histological changes of renal biopsy after 20 years. A: Masson, × 200. Multifocal and patchy atrophy of renal tubules, multifocal and patchy lymphocytic infiltration of renal interstitium with fibrosis (black arrow), and thickening of arterioles (white arrow); B: Periodic acid-silver methenamine, × 400. Mild segmental hyperplasia of glomerular mesangial cells and matrix, and segmental sclerosis (yellow arrow); C and D: Microvillous transformation of podocytes and extensive fusion of foot processes (C: × 6000, blue arrow; D: × 12000).