Case Report
Copyright ©The Author(s) 2022.
World J Clin Cases. Jun 16, 2022; 10(17): 5899-5909
Published online Jun 16, 2022. doi: 10.12998/wjcc.v10.i17.5899
Table 1 Case and literature reports of patients with MLC sonographic features
Ref.
Country
Age/gender
Clinical manifestation
Organs originated
US features
CEUS features
Contrast agent/dosage
Treatment
Follow-up
Zhou J et al[22], 2017China33/FIncrease in calcitonin and CEAMTCHyper-and net-like; echogenicity, clear margin, well-defined shapeHyper-enhancement during the arterial phase and hypo-enhancement in portal and parenchyma phaseSonovue 1.2 mLSurgery Calcitonin and CEA remained normal
Corvino et al[42], 2015Italy41/MNo specific symptomsRectal melanoma Solitary hypo-anechoic complex cystic lesion with a thin internal septum Hyper-enhancement of the cystic wall and intra-cystic septation during the arterial phase, rapid wash-out, and hypo-enhancement during the portal and late phasesSonovue 2.4 mLSurgery N/A
Toni et al[23], 2011Germany36/MNo specific symptomsChoroidal melanomaIso-echogenicityHomogeneous hyper-enhancement in arterial phase; hypo-enhancement in portal phase and punched-out enhancement defect; in late phaseSonovue 2.0 mLSurgeryN/A
Paulatto et al[25], 2020France74/MN/ANOS of colonN/ACentral part remains hypoechoicN/ASurgeryN/A
Ishikawa et al[43], 2021JapanN/AN/APancreasRound with irregular marginStrong peripheral enhancement in the arterial phase, early washout, hypo-enhancement in the portal, and post-vascular phases Sonazoid 0.015 mL/kgN/AN/A
Michima et al[24], 2016JapanN/AN/ABreastClearly round, oval, or lobulated solid focal lesions, irregular margin.Hypoechoic defects in enhancing parenchyma in the portal venous or postvascular phaseSonazoid 0.015 mL/kgN/AN/A
Yang DP et al[26], 2020ChinaN/AN/AColorectumHypo- or mix- echogenicity and anechoic areaCapsule enhancement, starting time of washout of > 40 s, un-enhancement area, and proportion of non-enhancement area > 50%Sonovue 2.4 mLN/AN/A
Wu et al[28], 2020ChinaN/AN/AColorectumNot mentionedPeripheral nodular enhancement, heterogeneous hyper-enhancement, or rim-like enhancement during the arterial phase and a non-enhancement area during the late phase Sonovue 2.0 mLN/AN/A
Schwarze et al[44], 2019GermanyN/AN/ANET of ileumAnechoic oval-shapedEarlier wash-in, hyperenhancement during the arterial phase, and hypo-enhancement in the portal phaseNot mentionedN/AN/A
Schwarze et al[44], 2019GermanyN/AN/APancreasN/AEarlier wash-in, hyperenhancement during the arterial phase, and hypo-enhancement during the portal phase Not mentionedN/AN/A
Zhang GD et al[29], 2013ChinaN/AN/AStomachRound with regular margin, iso-echoEarlier rim-like enhancement and washed out in portal phase, non-enhancement in late phaseSonovue 2.4 mLN/AN/A
Zhang GD et al[29], 2013ChinaN/AN/ALungOval and hypo-echoNo significant enhancement, hypo-perfusion compared with liver parenchymaSonovue 2.4 mLN/AN/A