Transition from minimal change disease to focal segmental glomerulosclerosis related to occupational exposure: A case report

Table 1 Temporal evolution of the laboratory parameters

Parameter	Time
	1 wk1				2 wk	3 wk2	4 wk3	1 yr4
Urinalysis
24hUP (mg/24 h)	10920				10320	11482.8	-	3320
mALB/Cr (mg/mmol)	866.95				-	-	-	339.06
RBCs (cells/HP)	18-20				8-12	7-10	-	1-2
DysEry (%)	> 80				> 75	> 70	-	-
Biochemical test
CR (μmol/L)	Pre-HD	1096	848.3	902.8	760	703	901.5	504.4
	Post-HD	587.7	528.6	596
BUN (mmol/L)	Pre-HD	34.26	22.27	22.8	14.64	13.48	23.11	15.38
	Post-HD	18.1	13.82	10.88
ALB (g/L)	22.3				21.2	22.4	22.7	36
CHO (mmol/L)	7.4				-	4.27	-	3.89
TG (mmol/L)	1.53				-	1.31	-	1.33
Blood toxicity elements test
Pb (μg/L)	32.8				-	-	-	24.3
Cd (μg/L)	2.8				-	-	-	1.5
As (μg/L)	6.4				-	-	-	5.1
Hg (μg/L)	0.2				-	-	-	< 0.1
Tl (μg/L)	< 0.1				-	-	-	0
Al (μg/L)	48.1				-	-	-	30
Mn (μg/L)	< 0.1				-	-	-	< 0.1

¹Time of hemodialysis (HD) and prednisolone acetate initiation. Kidney function tests pre- and post-HD were observed in the following weeks.

²Try stopping HD for 1 wk.

³Time of repeat kidney biopsy, discontinuing the prednisolone acetate, and entering maintenance HD.

⁴Laboratory examination after 1 yr of follow-up.

“-”: No results; 24hUP: 24-h urinary protein; mALB/Cr: Urinary microalbumin to creatinine ratio; RBCs: Red blood cells; DysEry: Dysmorphic erythrocytes ratio; CR: Creatinine; BUN: Blood urea nitrogen; ALB: Albumin; CHO: Total cholesterol; TG: Triglyceride; Pb: Lead; Cd: Cadmium; As: Arsenic; Hg: Mercury; Tl: Thallium; Al: Aluminum; Mn: Manganese.