Detection of a novel panel of 24 genes with high frequencies of mutation in gastric cancer based on next-generation sequencing

Table 3 Correlation of TP53 mutations with the clinicopathological features of the custom panel and the cBioPortal database

Clinicalinformation	Custom panel		P value	cBioPortal database		P value
	Wild	Mutated		Wild	Mutated
Age
≤ 65	16	19	0.530	60	48	0.878
> 65	11	18		79	68
Unknown	0	0		2	1
Sex
Male	19	31	0.200	86	70	0.849
Female	8	6		55	47
T classification
T1	10	10	0.716	6	5	0.451
T2	13	20		23	20
T3	4	6		67	66
T4	0	1		39	24
Unknown	0	0		6	2
N classification
N0	7	17	0.310	45	42	0.929
N1	10	8		29	25
N2	2	4		29	23
N3	8	8		31	23
Unknown	0	0		7	4
M classification
M0	25	33	0.645	127	111	0.040
M1	2	4		14	4
Unknown	0	0		0	2
clinical stage
Stage I	6	4	0.414	17	15	0.255
Stage II	9	19		51	51
Stage III	11	12		50	42
Stage IV	1	2		14	4
Unknown	0	0		9	5
Lauren class
Diffuse	12	10	0.059	44	18	0.017
Intestinal	13	27		81	88
Mixed	2	0		10	6
Unknown	0	0		6	5