Solute carrier family 2 members 1 and 2 as prognostic biomarkers in hepatocellular carcinoma associated with immune infiltration

Figure 6 The String database was used to predict the effects of solute carrier family 2 member 1, solute carrier family 2 member 2, and frequently altered adjacent genes expression changes on functions and pathways. A: The protein-protein interaction networks of solute carrier family 2 member 1 (SLC2A1), solute carrier family 2 member 2 (SLC2A2), and their neighbor genes in the String database were constructed, which contained 22 nodes and 107 edges. In this networks diagram, genes tumor protein p53, ATM serine/threonine kinase, MDM2 proto-oncogene, protein kinase-B, hypoxia inducible factor 1 subunit alpha, binding protein p300, insulin, glucokinase, and hexokinase 2 were included; B: SLC2A1, SLC2A2, and their neighbors were analyzed by Kyoto Encyclopedia of Genes and Genomes, and the top 20 genes were ranked by P value from small to large in the String database; C: SLC2A1, SLC2A2, and their neighbors were analyzed by biological process (BP), and the top 20 genes were ranked by P value from small to large in the String database; D: SLC2A1, SLC2A2, and their neighbors were analyzed by biological process (MF), and the top 20 genes were ranked by P value from small to large in the String database; E: SLC2A1, SLC2A2, and their neighbors were analyzed by cellular component (CC), and the top 20 genes were ranked by P value from small to large in the String database. HIF1AN: Hypoxia inducible factor 1 subunit alpha inhibitor; GSK3B: Glycogen synthase kinase 3 beta; GIPC1: GIPC PDZ domain containing family member 1; CREBBP: CREB binding protein; BCL2L1: BCL2 Like 1; VHL: von Hippel-Lindau tumor suppressor; SMUG1: Single-strand-selective monofunctional uracil-DNA glycosylase 1; SLC5A1: Solute carrier family 5 member 1; NOS3: Nitric oxide synthase 3; INSR: Insulin receptor; HNF1A: HNF1 homeobox A.