Solute carrier family 2 members 1 and 2 as prognostic biomarkers in hepatocellular carcinoma associated with immune infiltration

doi:10.12998/wjcc.v10.i13.3989

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 10, Issue 13

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (3228)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-9) series, Tables (1-4) series.

Item

Count

PDF

206

WORD

HTML

1694

Figures (1-9)

259

Tables (1-4)

205

Sum=2421

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

262

Download

545

Sum=807

May 6, 2022 (publication date) through May 23, 2024

Times Cited of This Article

Times Cited (7)

Journal Information of This Article

Publication Name

World Journal of Clinical Cases

ISSN

2307-8960

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical and Translational Research

World J Clin Cases. May 6, 2022; 10(13): 3989-4019
Published online May 6, 2022. doi: 10.12998/wjcc.v10.i13.3989

Table 3 Correlation analysis between solute carrier family 2 member 1 and solute carrier family 2 and genes markers of immune cells in tumor immune estimation resource

Description	Gene markers	Solute carrier family 2 member 1				Solute carrier family 2 member 2
		None		Purity		None		Purity
		cor	P value	cor	P value	cor	P value	cor	P value
CD8+ T cell
	CD8A	0.216	2.88E-05	0.173	1.27E-03	-0.103	4.85E-02	-0.027	6.15E-01
	CD8B	0.229	8.60E-06	0.195	2.72E-04	-0.199	1.14E-04	-0.138	1.04E-02
T cell (general)
	CD3D	0.241	2.75E-06	0.22	3.73E-05	-0.327	1.33E-10	-0.276	1.88E-07
	CD3E	0.201	1.01E-04	0.162	2.59E-03	-0.165	1.44E-03	-0.087	1.08E-01
	CD2	0.178	5.64E-04	0.138	1.04E-02	-0.194	1.75E-04	-0.121	2.48E-02
B cell
	CD19	0.208	5.50E-05	0.176	1.04E-03	-0.137	8.06E-03	-0.089	9.95E-02
	CD79A	0.099	5.72E-02	0.045	4.01E-01	-0.138	7.84-03	-0.07	1.92E-01
Monocyte
	CD86	0.413	0.00E+00	0.415	8.08E-16	-0.196	1.50E-04	-0.15	5.21E-03
	CD115 (CSF1R)	0.41	0.00E+00	0.408	3.06E-15	-0.175	7.02E-04	-0.126	1.96E-02
Tumor-associated macrophage
	CCL2	0.206	6.86E-05	0.162	2.53E-03	-0.117	2.47E-02	-0.042	4.32E-01
	CD68	0.38	4.24E-14	0.381	2.40E-13	-0.235	5.28E-06	-0.192	3.26E-04
	IL10	0.326	1.26E-10	0.309	4.43E-09	-0.131	1.15E-02	-0.078	1.48E-01
M1 macrophage
	INOS (NOS2)	0.068	1.91E-01	0.052	3.39E-01	0.175	7.12E-04	0.18	7.95E-04
	IRF5	0.142	6.33E-03	0.138	1.05E-02	0.011	8.39E-01	0.003	9.63E-01
	COX2 (PTGS2)	0.32	2.91E-10	0.313	2.80E-09	-0.06	2.45E-01	-0.007	9.03E-01
M2 macrophage
	CD163	0.28	3.94E-08	0.253	1.91E-06	0.046	3.72E-01	0.125	2.00E-02
	VSIG4	0.353	3.65E-12	0.336	1.56E-10	-0.06	2.46E-01	-0.007	8.96E-01
	MS4A4A	0.337	3.49E-11	0.33	3.15E-10	-0.057	2.69E-01	0.01	9.85E-01
	CD66b (CEACAM8)	0.086	9.68E-02	0.084	1.20E-01	-0.036	4.89E-01	-0.027	6.12E-01
	CD11b (ITGAM)	0.428	0.00E+00	0.405	4.71E-15	-0.18	5.06E-04	-0.156	3.75E-03
	CCR7	0.088	8.89E-02	0.016	7.70E-01	-0.032	5.35E-01	-0.045	4.00E-01
	KIR2DL1	0.083	1.09E-01	0.063	2.46E-01	-0.003	9.51E-01	0.019	7.23E-01
	KIR2DL3	0.179	5.16E-04	0.167	1.82E-03	-0.006	9.15E-01	-0.038	4.79E-01
	KIR2DL4	0.234	5.38E-06	0.212	7.12E-05	-0.133	1.06E-02	-0.107	4.78E-02
	KIR3DL1	0.146	4.97E-03	0.12	2.64E-02	0.079	1.30E-01	0.116	3.15E-02
	KIR3DL2	0.098	6.04E-02	0.08	1.38E-01	-0.027	6.02E-01	0.003	9.60E-01
	KIR3DL3	0.06	2.53E-01	0.046	3.91E-01	-0.021	6.91E-01	-0.015	7.87E-01
	KIR2DS4	0.117	2.39E-02	0.13	1.57E-02	0.04	4.37E-01	0.052	3.37E-01
	HLA-DPB1	0.319	4.21E-10	0.296	2.07E-08	-0.191	2.25E-04	-0.138	1.03E-02
	HLA-DQB1	0.221	1.77E-05	0.192	3.35E-04	-0.219	2.09E-05	-0.171	1.43E-03
	HLA-DRA	0.35	5.25E-12	0.326	5.24E-10	-0.117	2.37E-02	-0.055	3.09E-01
	HLA-DPA1	0.338	3.01E-11	0.316	1.92E-09	-0.114	2.88E-02	-0.052	3.34E-01
	BDCA-1 (CD1C)	0.061	2.45E-01	0.024	6.52E-01	0.004	9.40E-01	0.073	1.77E-01
	BDCA-4 (NRP1)	0.357	1.99E-12	0.352	1.70E-11	0.043	4.13E-01	0.087	1.08E-01
	CD11c (ITGAX)	0.382	2.93E-14	0.38	2.50E-13	-0.154	2.93E-03	-0.118	2.86E-02
Th1
	T-bet (TBX21)	0.095	6.88E-02	0.042	4.32E-01	0.025	6.38E-01	0.116	3.07E-02
	STAT4	0.082	1.13E-01	0.045	4.04E-01	-0.106	4.22E-02	-0.058	2.84E-01
	STAT1	0.314	7.29E-10	0.29	4.18E-08	0.023	6.52E-01	0.058	2.84E-01
	IFN-γ (IFNG)	0.237	3.81E-06	0.212	7.39E-05	-0.169	1.09E-03	-0.122	2.31E-02
	TNF-α (TNF)	0.277	6.15E-08	0.257	1.34E-06	-0.147	4.67E-03	-0.092	8.91E-02
Th2
	GATA3	0.248	1.34E-06	0.235	1.03E-05	-0.176	6.76E-04	-0.108	4.52E-02
	STAT6	0.27	1.35E-07	0.255	1.63E-06	0.178	5.68E-04	0.19	3.82E-04
	STAT5A	0.37	1.83E-13	0.338	1.18E-10	-0.097	6.27E-02	-0.055	3.12E-01
	IL13	-0.081	1.19E-01	-0.113	3.56E-02	0.077	1.38E-01	0.09	9.40E-02
Tfh
	BCL6	0.267	2.04E-07	0.281	1.16E-07	0.227	1.08E-05	0.228	1.94E-05
	IL21	0.124	1.65E-02	0.13	1.55E-02	-0.065	2.15E-01	-0.06	2.68E-01
Th17
	IL17A	-0.047	3.68E-01	-0.033	5.46E-01	0.04	4.47E-01	-0.051	3.41E-01
T cell regulatory
	FOXP3	0.068	1.89E-01	-0.039	4.68E-01	0.169	1.07E-03	0.189	4.24E-04
	CCR8	0.286	1.95E-08	0.264	6.44E-07	-0.056	2.79E-01	-0.008	8.86E-01
	STAT5B	0.156	2.63E-03	0.173	1.29E-03	0.402	0.00E+00	0.397	1.83E-14
	TGFβ (TGFB1)	0.314	7.92E-10	0.303	8.83E-09	-0.281	4.30E-08	-0.242	5.53E-06
T cell exhaustion
	PD-1 (PDCD1)	0.256	5.91E-07	0.232	1.31E-05	-0.281	3.50E-08	-0.238	7.71E-06
	CTLA4	0.284	2.57E-08	0.266	5.31E-07	-0.327	1.15E-10	-0.283	8.93E-08
	LAG3	0.156	2.67E-02	0.127	1.83E-02	-0.195	1.66E-04	-0.165	2.15E-03
	TIM-3 (HAVCR2)	0.434	0.00E+00	0.437	1.52E-17	-0.255	6.91E-07	-0.228	1.89E-05
	GZMB	0.176	6.91E-04	0.131	1.51E-02	-0.124	1.70E-02	-0.068	2.10E-01

cor: Correlation coefficient; L10: Interleukin 10; INOS: Nitric oxide synthase 2; IRF5: Interferon regulatory factor 5; COX2: Cytochrome c oxidase subunit II; VSIG4: V-set and immunoglobulin domain containing 4; MS4A4A: Membrane spanning 4-domains A4A; CCR7: C-C motif chemokine receptor 7; KIR2DL1: Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1; KIR2DL3: Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3; KIR2DL4: Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4; KIR3DL1: Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1; KIR3DL2: Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2; KIR3DL3: Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3; KIR2DS4: Killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4; HLA-DPB1: Major histocompatibility complex, class II, DP beta 1; HLA-DQB1: Major histocompatibility complex, class II, DQ beta 1; HLA-DRA: Major histocompatibility complex, class II, DR alpha; HLA-DPA1: Major histocompatibility complex, class II, DP alpha 1; BDCA-4: Neuropilin 1; T-bet: T-box transcription factor 21; STAT4: Signal transducer and activator of transcription 4; STAT1: Signal transducer and activator of transcription 1; IFN-γ: Interferon gamma; TNF-α: Tumor necrosis factor; GATA3: GATA binding protein 3; STAT6: Signal transducer and activator of transcription 6; STAT5A: Signal transducer and activator of transcription 5A; IL13: Interleukin 13; BCL6: BCL6 transcription repressor; IL21: Interleukin 21; IL17A: Interleukin 17A; FOXP3: Forkhead box P3; CCR8: C-C motif chemokine receptor 8; STAT5B: Signal transducer and activator of transcription 5B; TGFβ: Transforming growth factor-beta; PD-1: Programmed cell death 1; CTLA4: Cytotoxic T-lymphocyte associated protein 4; LAG3: Lymphocyte activating 3; TIM-3: Hepatitis A virus cellular receptor 2; GZMB: Granzyme B; Tfh: Follicular helper T.

Citation: Peng Q, Hao LY, Guo YL, Zhang ZQ, Ji JM, Xue Y, Liu YW, Lu JL, Li CG, Shi XL. Solute carrier family 2 members 1 and 2 as prognostic biomarkers in hepatocellular carcinoma associated with immune infiltration. World J Clin Cases 2022; 10(13): 3989-4019
URL: https://www.wjgnet.com/2307-8960/full/v10/i13/3989.htm
DOI: https://dx.doi.org/10.12998/wjcc.v10.i13.3989