Tuberculosis-associated hemophagocytic lymphohistiocytosis misdiagnosed as systemic lupus erythematosus: A case report

Table 1 Relative weights of the additive classification criteria items (with antinuclear antibody positivity as the entry criterion)

Domain	Item	Our case	Relative weights
Constitutional	Fever	39.7°C	2
Hematological	Leukopenia	1.28 x 109/L	3
	Thrombocytopenia	64 x 109/L	4
	Autoimmune hemolysis	N	4
Neuropsychiatric	Delirium	N	2
	Psychosis	N	3
	Seizure	N	5
Mucocutaneous	Alopecia	N	2
	Oral ulcers	N	2
	Subacute cutaneous or discoid lupus	N	4
	Acute cutaneous lupus	N	6
Serosal	Effusion	CT scan revealed pleural effusion	5
	Acute pericarditis	N	6
Musculoskeletal	Joint involvement	N	6
Renal	Proteinuria	Proteinuria (1.15 g/24 h)	4
	Class II/V	N	8
	Class III/IV	N	10
APL antibodies	Anti-phospholipid antibodies	APL antibodies were positive	2
Complements	C3 or C4 low	C3 level was reduced (0.50 g/L)	3
	C3 and C4 low	N	4
SLE-specific antibodies	Anti-Sm	Sm antibodies were positive	6
	Anti-dsDNA	N	6

The patient’s systemic lupus erythematosus (SLE) classification score was 26 according to the 2019 EULAR/ACR classification criteria. SLE can be diagnosed based on a score of 10 or more if the entry criterion is fulfilled. SLE: Systemic lupus erythematosus.