Wilson disease — the impact of hyperimmunity on disease activity: A case report

Figure 1 The liver biopsy images. A: Liver biopsy revealing mild microvesicular steatosis as several single as well as grouped ballooned hepatocytes (arrows, hematoxylin-eosin); B: Ceroid-laden macrophages (asterisks) are present in portal tracts indicating past cell damage (D-Periodic Acid-Schiff); C: Copper staining revealed mild copper accumulation (arrow). Note, several glycogenated nuclei (asterisk); D: Mild portal, perisinusoidal and initial septal fibrosis (modified Gomori). Original magnification: 200-fold.

Figure 2 Elevated transaminases (aspartate aminotransferase or alanine aminotransferase) as function of antinuclear antibodies and immunoglobulin G levels. Statistical analysis calculated the difference in prevalence of liver inflammation between the groups. The Chi² statistics with Yates correction is 172.484. The P value is < 0.00001. ANA: Antinuclear antibodies; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.