Splenic hamartomas in children

Figure 1 Possible etiopathogenesis of splenic hamartoma.

Figure 2 Gross appearance of splenic hamartoma. A nodular circumscribed unencapsulated lesion is visible on the cross-section, representing splenic hamartoma.

Figure 3 Microscopic images of the splenic hamartoma. A: Splenic hamartoma adjacent to normal splenic parenchyma was observed in the upper left of the panel, and compressed splenic parenchyma was observed in the lower right [hematoxylin and eosin (HE) × 50]; B: The lesion was composed of disorganized vascular channels lined by endothelial cells without significant cytological atypia (HE × 200); C: No mitosis or atypical cells were observed (HE × 400).

Figure 4 Immunohistochemical staining of the splenic hamartoma. A: CD8 was positive in the lining cells of vascular channels and in rare lymphocytes (× 200); B: Strong staining for CD31 was observed in the lesion (× 200); C: The lining cells of sinus-like spaces in the hamartoma were immunoreactive for CD34 (× 200).