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Copyright ©The Author(s) 2020.
World J Nephrol. Jun 30, 2020; 9(1): 1-8
Published online Jun 30, 2020. doi: 10.5527/wjn.v9.i1.1
Table 3 Dose adjustment for antiepileptic drugs in patients with renal impairment
GFR (mL/min)60-9030-6015-30< 15Haemodialysis
Levetiracetam500-1000 mg BD250-750 mg BD250-500 mg BD500-1000 mg ODPlus 250-500 mg/d
Toparimate50% decrease50% decrease50% decrease50-100 mg after HD
Zonisamide100-400 mg100-400 mg
Oxcarbazepine300-600 mg BD300-600 mg BD300 mg/d starting doseNANA
EsclicarbazepineNone400-600 mg OD400-600 mg OD
ClobazamNoneNoneNoneNANone
PregabalinNone50% decrease25-125 mg/d25-75 mg /d25-150 mg after HD
LacosamideNoneNone300 mg/dPlus < 50% after HD
RufinamideNoneNoneNoneNAPlus 30% after HD
Vigabatrin25% decrease50% decrease75% decreaseNANA
TiagabineNoneNoneNoneNoneNone
LamotrigineNoneNoneNoneNoneNA
PhenytoinNoneNoneNoneNoneMay need in high flux HD
CarbamazepineNoneNANA75% dosePlus 75% after HD
ValproateNoneNoneNoneNoneMay need in high flux HD
PerampanelNoneNoneNANANA
BrivaracetamNoneNoneNANANone