Review
Copyright ©The Author(s) 2018.
World J Nephrol. Mar 6, 2018; 7(2): 51-57
Published online Mar 6, 2018. doi: 10.5527/wjn.v7.i2.51
Table 2 Summary of vasopressin limitations compared to copeptin advantages as a biomarker using the thermo scientific B.R.A.H.M.S KRYPTOR assay (adapted from Thermo Fisher scientific)
FeaturesLimitations of measuring AVPAdvantages of CT-proAVP (Copeptin)
Ex vivo stabilityUnstable (even at -20 °C)Stable at > 3 d at room temperature
Sample volume required400 L50 μL
Time to results3 working daysapproximately 1 h
SensitivityLow (small molecule size, measured only by competitive immunoassay)High (larger size, can be measured using a sensitive sandwich immunoassay)
Measuring range1.15-73.8 pmol/L0.7-500 pmol/L and up to 2000 pmol/L with automated dilution
HandlingManualAutomatic