Review
Copyright ©The Author(s) 2018.
World J Nephrol. Jan 6, 2018; 7(1): 29-40
Published online Jan 6, 2018. doi: 10.5527/wjn.v7.i1.29
Table 6 Two proposed criteria for IgG4-TIN by the Mayo Clinic and the Japanese Society of Nephrology
CriterionThe Mayo Clinic criteriaJSN criteria
HistologyPlasma cell-rich TIN with > 10 IgG4+ plasma cells/HPF in the most concentrated field (mandatory criterion) TBM immune complex deposits by immunofluorescence, immunochemistry, and/or electron microscopyDense lymphoplasmacytic infiltrate with > 10 IgG4+ plasma cells/HPF and/or IgG4/IgG+ plasma cell ratio of > 40%; Characteristic storiform fibrosis
ImagingSmall peripheral low-attenuation cortical nodules, round or wedge-shaped lesions, or diffuse patchy involvementMultiple low-density lesions or enhanced CT, diffuse kidney enlargement, hypovascular solitary nodule, hypertrophic lesion of the renal pelvic wall
SerologyElevated serum IgG4 or total IgG levelElevated serum IgG4 or total IgG level
Clinical featuresNoneClinical or laboratory evidence of kidney damage
Other organ involvementCharacteristic findings of IgG4-RD in other organsCharacteristic findings of IgG4-RD in other organs
Definite IgG4-TINThe histologic feature and at least one other feature from imaging, serology or other organ involvementThe histologic feature (a and b) and at least two of other features from imaging, serology or other organ involvement