Review
Copyright ©The Author(s) 2018.
World J Nephrol. Jan 6, 2018; 7(1): 1-28
Published online Jan 6, 2018. doi: 10.5527/wjn.v7.i1.1
Table 2 Formulas for treatment of dysnatremias with saline or water infusions
Hypotonic hyponatremia
Change in sodium concentration after infusion of 1 L of saline. Adrogué-Madias formula[41]:
[Na]Final - [Na]Initial = ([Na]Infusate - [Na]Initial)/(TBWInitial + 1)
Volume of saline required for a targeted serum sodium concentration[84]:
VInfusate = TBWInitial × ([Na]Targeted - [Na]Initial)/[Na](Infusate - [Na]Targeted)
Hypernatremia
Volume of D5/W required for a targeted serum sodium concentration[37]:
VInfusate = TBWInitial × ([Na]Initial - [Na]Targeted)/[Na]Targeted
Volume of hypotonic saline required for a targeted serum sodium concentration[37]:
VInfusate = TBWInitial × ([Na]Initial - [Na]Targeted)/([Na]Targeted - [Na]Infusate)