Application of established pathophysiologic processes brings greater clarity to diagnosis and treatment of hyponatremia

Table 2 Summary of extracellular volume expansion with isotonic, hypotonic and hypertonic saline on fractional excretion of sodium [FEsodium] and urate [FEurate] at control and experimental periods after saline administration. Note the meager changes in FEurate despite very high FENa

	FENa (%)		FEurate (%)		Ref.
	Control	Exp	Control	Exp
Isotonic	1.04	4.43	7.98	9.76	[36]
	1.6	8.2	5.0	5.8	[35]
Hypertonic	2.9	18.6	5.4	12.1	[35]
	1.4	14.5	12.5	18.7	[34]
Hypotonic	1.1	6.1	4.0	7.3	[35]

Printed with permission Ref. [26]. Exp: Experimental.