Constitutive renal Rel/nuclear factor-κB expression in Lewis polycystic kidney disease rats

Table 2 Renal function for male Lewis and Lewis polycystic kidney rats from weeks 3 to 20

Parameter		Week 3	Week 6	Week 10	Week 16	Week 20
24 h urine volume (mL)	Lewis	ND	6 ± 1	9 ± 2	9 ± 2	ND
	LPK	ND	7 ± 1	25 ± 2b	23 ± 9b	ND
Serum creatinine (μmol/L)	Lewis	24 ± 3	22 ± 5	29 ± 10	24 ± 1	27 ± 5
	LPK	20 ± 2a	28 ± 14	33 ± 3b	63 ± 9	191 ± 38b
Endogenous CrCl (mL/min)	Lewis	ND	0.5 ± 0.2	1.8 ± 0.3	2.5 ± 0.6	ND
	LPK	ND	0.5 ± 0.2	0.8 ± 0.1b	0.6 ± 0.2b	ND
CrCl/BW (fold-change over Lewis)	Lewis	ND	1 ± 0.4	1.6 ± 0.1	1.7 ± 0.3	ND
	LPK	ND	0.9 ± 0.3	0.8 ± 0.1b	0.4 ± 0.1b	ND
Serum urea (mmol/L)	Lewis	5 ± 1	6 ± 1	6 ± 1	6 ± 1	8 ± 1
	LPK	7 ± 0b	8 ± 1b	14 ± 1b	22 ± 3b	44 ± 4b

Data expressed as mean ± SD;

^aP < 0.05 vs age-matched Lewis male animals;

^bP < 0.01 vs age-matched Lewis male animals. BW: Body weight; CrCl: Creatinine clearance; ND: Not determined.