Renal dopaminergic system: Pathophysiological implications and clinical perspectives

Figure 2 Impaired renal dopaminergic system and its association with hypertension. Red full squares and arrows indicate those factors that promote the impairment of renal dopamine; blue dotted squares and arrows indicate those factors that enhance renal dopaminergic system. IR: Insulin-resistance; COMT: Catechol-O-methyl-transferase; MAO: Monoamine-oxidase: AT1: Angiotensin II receptor subtype 1; AT2: Angiotensin II receptor subtype 2; COX-2: Cyclooxygenase type 2; ANP: Atrial natriuretic peptide; NPR-A: Natriuretic peptide receptor type A; LATs: L-aminoacids transporters; OCTs: Organic cationic transporters; GRK4: G-protein receptor kinase 4.