Searching for a treatment for Alport syndrome using mouse models

doi:10.5527/wjn.v3.i4.230

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Nov 6, 2014 (publication date) through Jun 4, 2024

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World Journal of Nephrology

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2220-6124

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Nephrol. Nov 6, 2014; 3(4): 230-236
Published online Nov 6, 2014. doi: 10.5527/wjn.v3.i4.230

Table 3 The effects of bone marrow transplantation therapy in COL4A3 -/- mice

	*Prodromidi et al[45]*		*Sugimot et al[46]*		*Katayama et al[47]*
	WT -> KO	KO -> KO	WT -> KO	KO -> KO	WT -> KO	KO -> KO
α3 (IV) IF	+	-	+	-	-	-
α3 (IV) WB	no data	no data	+	-	-	-
Col4a3 mRNA	+	-	+	-	+	-
BUN and Cr	improved	no change	improved	no change	improved	improved
Renal pathology	improved	no change	improved	no change	improved	improved
Survival (d)	no data	no data	no data	no data	125	135

WT: Wild-type; KO: Knockout; IF: Immunofluorescence; WB: Western blot; BUN: Blood urea nitrogen; Cr: Creatinine.

Citation: Katayama K, Nomura S, Tryggvason K, Ito M. Searching for a treatment for Alport syndrome using mouse models. World J Nephrol 2014; 3(4): 230-236
URL: https://www.wjgnet.com/2220-6124/full/v3/i4/230.htm
DOI: https://dx.doi.org/10.5527/wjn.v3.i4.230