Searching for a treatment for Alport syndrome using mouse models

Table 2 The efficacy of pharmacological drugs in COL4A3 -/- mice

Drug	Survival (d)	Efficacy
Vasopeptidase inhibitor[22]	172	(+++)
ACE inhibitor[23]	150	(+++)
ARB[24]	98	(++)
HMG-CoA reductase inhibitor[26]	91	(++)
CCR1 inhibitor[27]	86	(+)
TNF-alpha antagonist[29]	81	(+)
Renin inhibitor[30]	78	(+)
Vitamin D analog[31]	75	(+)
Untreated (129SvJ background)	71

ACE: Angiotensin converting enzyme; ARB: Angiotensin-II receptor blocker; CCR1: Chemokine (CC motif) receptor 1; HMG-CoA: 3-hydroxy-3-methylglutaryl-coenzyme A; TNF: Tumor necrosis factor.