Renin-angiotensin system in the kidney: What is new?

Table 2 Most common drugs already established for clinical use and emerging drugs and new targets for the treatment of hypertension, cardiovascular and renal diseases

Target	Drug	Therapy	Clinical use
Renin	Aliskiren	HTN, RF	+
	Remikiren, enalkiren	HTN	+
ACE	Captopril, lisinopril, trandolapril	HTN, HF, LVD, DN	+
	Enalapril, enalaprilat, fosinopril, ramipril	HTN, HF	+
	Moexipril, quinapril, perindopril, benazepril	HTN	+
AT1	Losartan, azilsartan, valsartan, ibesartan, candesartan, telmisartan, eprosartan, omesartan	HTN, HF	+
Mas	AVE 0991	HTN	-
	Ang-(1-7)-CyD	HF	-
ACE2	Xanthenone	HTN, RF, HF	-

+: Already used in clinic; –: Not used in clinic yet. ACE: Angiotensin converting enzyme; ACE2:Angiotensin converting enzyme 2; AT1: Angiotensintype 1 receptor; Mas: Ang-(1-7) Mas receptor; RF: Renal failure; HF: Heart failure; HTN: Hypertension; LVD: Left ventricular dysfunction; DN: Diabetic nephropathy.