Long-term outcome of ketoconazole and tacrolimus co-administration in kidney transplant patients

Table 2 Tacrolimus dose, trough level and kidney function in the two groups

	1 wk	1 mo	2 mo	1 yr	3 yr	5 yr
Tacrolimus dose (mg/d)
Group 1	10.9 ± 5.6	7.5 ± 4.8	6.0 ± 3.6	5.6 ± 3.8	5.3 ± 3.1	4.9 ± 2.8
Group 2	8.6 ± 4.1	8.3 ± 3.7	8.1 ± 3.2	7.8 ± 3.0	7.0 ± 2.2	6.2 ± 2.5
P value	0.004	0.03	< 0.001	< 0.001	< 0.001	< 0.001
Tacrolimus trough level (× 10 mg/L)
Group 1	11.3 ± 2.1	9.7 ± 1.9	9.3 ± 1.7	8.6 ± 2.1	6.4 ± 1.9	5.3 ± 1.4
Group 2	10.7 ± 1.8	10.2 ± 2.0	9.5 ± 1.6	9.0 ± 1.8	5.8 ± 1.7	4.8 ± 1.5
Serum Cr (× 10 mg/L)
Group 1	2.2 ± 1.3	1.7 ± 1.1	1.5 ± 0.9	1.6 ± 1.2	1.6 ± 0.8	1.7 ± 0.9
Group 2	1.9 ± 1.1	1.7 ± 0.9	1.6 ± 0.7	1.5 ± 0.8	1.5 ± 0.7	1.6 ± 0.8