Immunofluorescence-based reclassification of idiopathic membranoproliferative glomerulonephritis: Insights from a single-center cohort

Table 5 Cox regression analysis for factors associated with disease remission and end-stage kidney disease among the two groups of membranoproliferative glomerulonephritis

Variables	Remission		ESKD		Remission		ESKD
	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
Blood pressure on admission	1.01 (0.34-1.46)	0.72	1.12 (0.71-1.8)	0.79	0.39 (0.11-1.16)	0.07	0.45 (0.22-1.8)	0.63
Proteinuria on admission (g/day)	1.25 (0.75-2.48)	0.29	0.84 (0.32-1.96)	0.89	0.38 (0.14-1.10)	0.06	0.53 (0.29-1.1)	0.54
Vasculopathy	0.97 (0.67-1.8)	0.07	1.58 (0.6-1.89)	0.62	0.43 (0.26-1.17)	0.24	1.2 (0.50-3.10)	0.04
Presence of crescents	0.27 (0.16-0.8)	0.07	0.49 (0.3-0.81)	0.32	1.02 (0.22-1.8)	0.08	1.3 (0.23-3.2)	0.02
IF/TA	1.1 (0.58-1.6)	0.24	1.45 (1.1-3.2)	0.02	1.9 (0.62-5.1)	0.19	1.5 (0.82-6.01)	0.07
Steroids alone	0.67 (0.54-2.1)	0.42	0.28 (0.16-1.27)	0.08	0.29 (0.16-1.15)	0.07	1.39 (0.16-4.01)	0.71
Cyclophosphamide	1.21 (0.48-2.75)	0.49	0.78 (0.2-1.8)	0.71	0.9 (0.30-2.0)	0.87	0.22 (0.23-1.96)	0.26

IF: Interstitial fibrosis; TA: Tubular atrophy; HR: Hazard ratio; CI: Confidence interval; ESKD: End-stage kidney disease.