Immunofluorescence-based reclassification of idiopathic membranoproliferative glomerulonephritis: Insights from a single-center cohort

Table 2 Comparison of histopathological characteristics between the two groups of membranoproliferative glomerulonephritis classified based on immunofluorescence results, median (interquartile rage)/n (%)

	IC-MPGN (n = 100)	C-MPGN (n = 28)	P value
Total glomeruli	16 (11-23)	16 (12-20)	0.924
Global sclerosis			0.725
None	54 (54)	14 (50)
25%	30 (30)	11 (39.3)
26%-50%	13 (13)	2 (7.1)
> 50%	3 (3)	1 (3.6)
Vasculopathy	28 (28)	14 (50)	0.028
Crescents			0.385
None	52 (52)	11 (39.3)
Cellular	39 (39)	15 (53.6)
Fibrocellular	9 (9)	2 (7.1)
IF/TA			0.270
None	15 (15)	2 (7.1)
Mild	63 (63)	23 (82.1)
Moderate	19 (19)	3(10.7)
Severe	3 (3)	0 (0.0)
Immunofluorescence results
IgG			0.000
Negative	11 (11)	17 (60.7)
Trace	2 (2)	3 (10.7)
+1	77 (77)	8 (28.6)
+2	9 (9)	0 (0)
+3	1 (1)	0 (0)
IgA			0.275
Negative	84 (84)	28 (100)
Trace	1 (1)	0 (0)
+1	12 (12)	0 (0)
+2	1 (1)	0 (0)
+3	2 (2)	0 (0)
IgM			0.001
Negative	56 (56)	26 (92.9)
Trace	0 (0)	0 (0)
+1	36 (36)	2 (7.1)
+2	8 (8)	0 (0)
+3	0 (0)	0 (0)
C3			0.000
Negative	10 (10)	0 (0)
Trace	4 (4)	0 (0)
+1	53 (53)	0 (0)
+2	27 (27)	9 (32.1)
+3	6 (6)	19 (67.9)
C1q			0.039
Negative	64 (64)	15 (53.6)
Trace	0 (0)	1 (3.6)
+1	24 (24)	12 (42.9)
+2	9 (9)	0 (0)
+3	3 (3)	0 (0)

Continuous variables were compared using the Mann-Whitney U test (or Student’s t-test for normally distributed data). Categorical variables were analyzed using χ² or Fisher’s exact test, as appropriate. IF: Interstitial fibrosis; TA: Tubular atrophy; IC-MPGN: Immune complex-mediated membranoproliferative glomerulonephritis; C-MPGN: Complement-mediated membranoproliferative glomerulonephritis.