Depression in chronic kidney disease and dialysis: A psychonephrology narrative review

doi:10.5527/wjn.121696

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World Journal of Nephrology

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2220-6124

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Nephrol. Sep 25, 2026; 15(3): 121696
Published online Sep 25, 2026. doi: 10.5527/wjn.121696

Table 5 Comparison of relevant studies on antidepressants in chronic kidney disease

Studies	ASCEND	CAST	CRIC
Study population	CKD on MHD	Non dialysis CKD	Non dialysis CKD
Study design	RCT	RCT	Prospective observational cohort
Depression severity	MDD	MDD	Moderate depression
Scale used	QIDS-C	QIDS	BDI
Study groups	CBT vs sertraline	Sertraline vs placebo	Sertraline vs placebo
Follow up	12 weeks	12 weeks	BDI repeated over years
Results	Sertraline leads to modest improvement in symptoms	Sertraline not superior than placebo	Antidepressants did not reduce the risk associated with depression

CKD: Chronic kidney disease; MHD: Maintenance hemodialysis; RCT: Randomized controlled trial; MDD: Major depressive disorder; QIDS-C: Quick Inventory of Depressive Symptomatology Clinician Rated; QIDS: Quick Inventory of Depressive Symptomatology; BDI: Beck depression inventory; CBT: Cognitive behavioral therapy.

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Citation: Yadav M, Kumar A, Pandey A, Singh S, Kumar R, Verma H, Mahajan S, Sharma S, Prasad P, Agarwal A. Depression in chronic kidney disease and dialysis: A psychonephrology narrative review. World J Nephrol 2026; 15(3): 121696
URL: https://www.wjgnet.com/2220-6124/full/v15/i3/121696.htm
DOI: https://dx.doi.org/10.5527/wjn.121696

Yadav M, Kumar A, Pandey A, Singh S, Kumar R, Verma H, Mahajan S, Sharma S, Prasad P, Agarwal A. Depression in chronic kidney disease and dialysis: A psychonephrology narrative review. World J Nephrol 2026; 15(3): 121696 [PMID: 42626288 DOI: 10.5527/wjn.121696]

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