Depression in chronic kidney disease and dialysis: A psychonephrology narrative review

doi:10.5527/wjn.121696

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 15, Issue 3

This Article

(17)

(19)

(0)

(459)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Nephrology

ISSN

2220-6124

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Minireviews

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Nephrol. Sep 25, 2026; 15(3): 121696
Published online Sep 25, 2026. doi: 10.5527/wjn.121696

Table 1 Role of inflammatory mediators in depression pathogenesis in chronic kidney disease

Inflammatory mediator	Depression mechanism	Key impact	Variation across different CKD stages
IL-6	Microglial activation, BBB permeability	HPA dysregulation, hippocampal loss	Increases progressively; significantly higher in stages 3-5
TNF-α	Serotonin ↓, NO ↑	Anhedonia, neuroinflammation	Mild progressive increase from stage 1 to stage 3, not always significant
CRP	Vascular damage, endothelial dysfunction	Cerebral hypoperfusion	Elevated in advanced stages (stage 4 and 5)

CKD: Chronic kidney disease; IL-6: Interleukin-6; BBB: Blood-brain barrier; HPA: Hypothalamic-pituitary-adrenal; TNF-α: Tumor necrosis factor-α; NO: Nitric oxide; CRP: C-reactive protein.

Full Size Table

Citation: Yadav M, Kumar A, Pandey A, Singh S, Kumar R, Verma H, Mahajan S, Sharma S, Prasad P, Agarwal A. Depression in chronic kidney disease and dialysis: A psychonephrology narrative review. World J Nephrol 2026; 15(3): 121696
URL: https://www.wjgnet.com/2220-6124/full/v15/i3/121696.htm
DOI: https://dx.doi.org/10.5527/wjn.121696

Yadav M, Kumar A, Pandey A, Singh S, Kumar R, Verma H, Mahajan S, Sharma S, Prasad P, Agarwal A. Depression in chronic kidney disease and dialysis: A psychonephrology narrative review. World J Nephrol 2026; 15(3): 121696 [PMID: 42626288 DOI: 10.5527/wjn.121696]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.