Role of fibroblast growth factor-23 in renal disease activity and bone density involvement in patients with lupus nephritis

Table 6 Laboratory characteristics of the studied patients based on bone mineral density status, n (%)/mean ± SD

Variables	Normal BMD (n = 47)	Low BMD (n = 53)	P value
Random blood sugar (mg/dL)	98.26 ± 15.06	107.42 ± 15.41	< 0.001
Complete blood count
Hemoglobin (g/dL)	9.25 ± 1.84	8.75 ± 1.41	0.13
Leucocytes (103/μl)	7.14 ± 2.40	6.54 ± 2.76	0.25
Platelets (103/μL)	293.74 ± 87.80	248.49 ± 104.66	0.02
Neutrophil/Lymphocyte ratio	1.22 ± 0.38	2.67 ± 0.56	< 0.001
Platelets/Lymphocytes ratio	156.89 ± 34.90	245.09 ± 56.90	< 0.001
Kidney function tests
Blood urea nitrogen (mg/dL)	19.14 ± 4.03	17.89 ± 1.76	0.78
Creatinine (μmol/L)	100.37 ± 13.97	214.60 ± 25.65	< 0.001
Proteinuria (mg/day)	2158.98 ± 276	3343.40 ± 362.98	0.01
Glomerular filtration rate (mL/minute/1.73 m2)	81.92 ± 32.64	63.68 ± 41.67	0.01
Urine analysis
Hematuria (HPF)	13.26 ± 3.64	9.23 ± 1.98	0.31
Pyuria (HPF)	10.11 ± 3.47	13.46 ± 2.31	0.24
Albuminuria			0.62
0	6 (12.8)	4 (7.5)
+	17 (36.2)	17 (32.1)
++	20 (42.6)	27 (50.9)
+++	3 (6.4)	5 (9.4)
++++	1 (2.1)	0 (0.0)
Coagulation profile
Prothrombin time (seconds)	11.88 ± 1.53	12.21 ± 176	0.43
Prothrombin concentration (%)	93.15 ± 13.93	94.11 ± 17.87	0.81
International normalized ratio	1.03 ± 0.17	1.03 ± 0.09	0.97
Bone parameters
Calcium (mg/dL)	8.01 ± 0.64	7.94 ± 0.65	0.55
Phosphorus (mg/dL)	4.07 ± 1.19	4.23 ± 1.98	0.56
Parathormone (pg/mL)	72.64 ± 33.56	101.22 ± 18.61	0.16
Vitamin D (ng/mL)	39.90 ± 9.05	22.36 ± 4.84	0.01
Alkaline phosphatase (U/L)	94.47 ± 6.45	85.81 ± 9.26	0.45
Complement
C3 (mg/dL)	100.98 ± 13.99	50.56 ± 12.98	< 0.001
C4 (mg/dL)	23.89 ± 6.78	9.05 ± 1.90	< 0.001

BMD: Bone mineral density; HPF: High-power field.