Role of fibroblast growth factor-23 in renal disease activity and bone density involvement in patients with lupus nephritis

Table 2 Laboratory characteristics of the studied groups, n (%)/mean ± SD

Variables	Inactive LN group (n = 50)	Active LN group (n = 50)	P value
Random blood sugar (mg/dL)	97.42 ± 15.38	108.80 ± 14.31	< 0.001
Complete blood count
Hemoglobin (g/dL)	9.11 ± 1.67	8.86 ± 1.63	0.45
Leucocytes (103/μL)	6.69 ± 2.32	6.98 ± 2.87	0.60
Platelets (103/μL)	233.86 ± 85.29	265.66 ± 106.99	0.97
Neutrophil/Lymphocyte ratio	2.09 ± 0.78	3.11 ± 1.01	< 0.001
Platelets/Lymphocytes ratio	198.11 ± 34.98	256.98 ± 67.89	< 0.001
Kidney function tests
Blood urea nitrogen (mg/dL)	17.90 ± 3.79	19.06 ± 1.90	0.78
Creatinine (μmol/L)	89.36 ± 8.62	232.72 ± 27.50	< 0.001
Proteinuria (mg/day)	1795.30 ± 154.37	3778.14 ± 407.98	< 0.001
Glomerular filtration rate (mL/minute/1.73 m2)	87.41 ± 4.81	57.10 ± 5.26	< 0.001
Urine analysis
Hematuria (HPF)	13.96 ± 3.73	10.07 ± 4.44	0.15
Pyuria (HPF)	10.18 ± 1.56	13.58 ± 2.38	0.93
Albuminuria			0.39
0	6 (1)	4 (8)
+	19 (38)	15 (30)
++	22 (44)	25 (50)
+++	2 (4)	6 (12)
++++	1 (2)	0
Coagulation profile
International normalized ratio	1.04 ± 0.11	1.02 ± 0.17	0.63
Bone parameters
Calcium (mg/dL)	8.07 ± 0.62	7.88 ± 0.66	0.14
Phosphorus (mg/dL)	4.12 ± 1.29	4.71 ± 1.97	0.07
Parathormone (pg/mL)	65.93 ± 17.49	110.24 ± 19.81	0.02
Vitamin D (ng/mL)	37.93 ± 8.52	27.52 ± 7.13	0.22
Alkaline phosphatase (U/L)	95.16 ± 6.33	84.60 ± 9.57	0.36
Complement
C3 (mg/dL)	95.60 ± 12.09	40.18 ± 7.80	< 0.001
C4 (mg/dL)	19.90 ± 3.33	5.55 ± 1.65	< 0.001
Positive antinuclear antibody	50 (100)	50 (100)	-
Positive anti-double-stranded DNA	50 (100)	50 (100)	-

HPF: High-power field; LN: Lupus nephritis.