Effect of pentoxifylline on inflammatory markers in non-diabetic chronic kidney disease patients: A prospective, interventional, open label

Table 3 Correlation among tumour necrosis factor-alpha and high-sensitivity C-reactive protein and participants’ age, blood pressure and laboratory parameters of the studied groups

	TNF-α (ng/L) after 6 months				hs-CRP (mg/L) after 6 months
	r value1 (group 1)	P value (group 1)	r value1 (group 2)	P value (group 2)	r value1 (group 1)	P value (group 1)	r value1 (group 2)	P value (group 2)
Age	0.100	0.667	-0.052	0.823	0.238	0.298	0.128	0.579
SBP after 6 months	0.072	0.756	0.304	0.180	0.237	0.302	0.049	0.832
DBP after 6 months	0.078	0.738	0.318	0.160	0.082	0.723	0.145	0.530
MAP after 6 months	0.112	0.629	0.020	0.933	0.094	0.685	0.073	0.754
Laboratory parameters
Hb (gm/dL)	-0.040	0.864	0.101	0.663	0.327	0.148	-0.102	0.659
WBCs (× 103/μl)	0.487	0.025a	0.083	0.720	-0.113	0.627	0.172	0.457
Platelet (× 103/μl)	-0.127	0.585	-0.063	0.786	0.043	0.852	0.242	0.291
BUN (mg/dL)	0.262	0.250	0.301	0.186	0.364	0.105	-0.206	0.371
Cr (mg/dL)	0.477	0.029a	0.579	0.006a	0.143	0.535	-0.185	0.423
Na (meq/L)	0.115	0.619	-0.071	0.761	0.102	0.658	0.222	0.334
K (meq/L)	-0.279	0.222	0.193	0.402	-0.397	0.075	0.117	0.613
Ca (mg/dL)	-0.269	0.238	-0.100	0.666	-0.365	0.104	0.454	0.039a
PO4 (mg/dL)	0.126	0.586	0.041	0.861	0.269	0.239	0.005	0.983
Intact PTH (pg/mL)	0.104	0.655	0.179	0.439	-0.326	0.150	-0.184	0.424
hs-CRP (mg/L) after 6 months	0.223	0.331	0.143	0.537	-	-	-	-
UPCR (mg/g) after 6 months	0.110	0.634	0.084	0.717	0.236	0.304	-0.120	0.604
eGFR (mL/minute/1.73 m2) after 6 months	-0.134	0.562	-0.440	0.046a	-0.057	0.805	-0.062	0.789

^aP value < 0.05.

¹Pearson coefficients.

SBP: Systolic blood pressure; DBP: Diastolic blood pressure; MAP: Mean arterial pressure; BUN: Blood urea nitrogen; Cr: Creatinine; Na: Sodium; K: Potassium; Ca: Calcium; PO₄: Phosphorus; PTH: Parathyroid hormone; WBC: White blood cell; Hb: Haemoglobin; hs-CRP: High-sensitivity C-reactive protein; UPCR: Urinary protein-to-creatinine ratio; eGFR: Estimated glomerular filtration rate; TNF-α: Tumour necrosis factor-alpha.