Effect of pentoxifylline on inflammatory markers in non-diabetic chronic kidney disease patients: A prospective, interventional, open label

doi:10.5527/wjn.120037

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World Journal of Nephrology

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2220-6124

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Nephrol. Sep 25, 2026; 15(3): 120037
Published online Sep 25, 2026. doi: 10.5527/wjn.120037

Table 2 Laboratory tests of the studied groups, mean ± SD

		Group 1 (n = 21)	Group 2 (n = 21)	t value¹	P value
BUN (mg/dL)		39.762 ± 4.158	43.238 ± 4.098	-2.729	0.009^a
Cr (mg/dL)		1.447 ± 0.068	1.486 ± 0.091	0.000	1.000
Na (meq/L)		139.429 ± 3.789	138.381 ± 4.642	0.801	0.428
K (meq/L)		4.448 ± 0.368	4.343 ± 0.379	0.909	0.369
Ca (mg/dL)		8.743 ± 0.578	8.700 ± 0.483	0.261	0.795
PO₄ (mg/dL)		4.810 ± 0.397	4.657 ± 0.514	1.074	0.289
PTH (pg/mL)		107.190 ± 8.675	105.095 ± 7.842	0.821	0.416
Hb (gm/dL)		11.114 ± 0.795	11.286 ± 0.857	-0.672	0.506
WBCs (× 10³/μL)		7.048 ± 1.024	7.048 ± 0.740	0.000	1.000
Platelet (× 10³/μL)		273.714 ± 65.293	303.524 ± 86.458	-1.261	0.215
hs-CRP (mg/L)	Baseline	3.071 ± 0.898	4.790 ± 0.774	-6.644	< 0.001^a
	After 6 months	3.119 ± 0.789	2.510 ± 0.744	2.575	0.014^a
	Differences	0.048 ± 1.172	-2.281 ± 1.114
	Paired test	0.854	< 0.001^a
UPCR (mg/mg)	Baseline	372.381 ± 28.444	388.571 ± 14.243	-2.332	0.025^a
	After 6 months	193.333 ± 26.520	150.000 ± 18.439	6.148	< 0.001^a
	Differences	-179.048 ± 22.114	-238.571 ± 25.157
	Paired test	< 0.001^a	< 0.001^a
eGFR (mL/minute/1.73 m²)	Baseline	51.048 ± 7.625	50.714 ± 7.163	-0.146	0.885
	After 6 months	51.667 ± 4.282	52.381 ± 4.566	0.523	0.604
	Differences	0.619 ± 6.704	1.667 ± 7.358
	Paired test	0.677	0.312
TNF-α (ng/L)	Baseline	174.762 ± 69.326	174.524 ± 70.156	0.011	0.991
	After 6 months	77.429 ± 28.046	66.286 ± 25.767	1.341	0.188
	Differences	-97.333 ± 43.510	-108.238 ± 44.983
	Paired test	< 0.001^a	< 0.001^a

^aP value < 0.05.

¹Students’ t-test.

BUN: Blood urea nitrogen; Cr: Creatinine; Na: Sodium; K: Potassium; Ca: Calcium; PO₄: Phosphorus; PTH: Parathyroid hormone; WBC: White blood cell; Hb: Haemoglobin; hs-CRP: High-sensitivity C-reactive protein; UPCR: Urinary protein-to-creatinine ratio; eGFR: Estimated glomerular filtration rate; TNF-α: Tumour necrosis factor-alpha.

Full Size Table

Citation: Abd El Mobdy AH, Hebah HA, Ezzat MA, Eid Mohamed BA, Ahmed FA. Effect of pentoxifylline on inflammatory markers in non-diabetic chronic kidney disease patients: A prospective, interventional, open label. World J Nephrol 2026; 15(3): 120037
URL: https://www.wjgnet.com/2220-6124/full/v15/i3/120037.htm
DOI: https://dx.doi.org/10.5527/wjn.120037

Abd El Mobdy AH, Hebah HA, Ezzat MA, Eid Mohamed BA, Ahmed FA. Effect of pentoxifylline on inflammatory markers in non-diabetic chronic kidney disease patients: A prospective, interventional, open label. World J Nephrol 2026; 15(3): 120037 [PMID: 42626272 DOI: 10.5527/wjn.120037]

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