Potential diagnostic role of urinary exosomal microRNAs in immunoglobulin A nephropathy: A case-control study

Table 9 The combination of these 9 microRNAs has the potential to diagnose immunoglobulin A nephropathy cases with an area under the receiver operating characteristic curve > 0.8¹

Discovery cohort with 9 miRNAs	hsa-miR-4532, hsa-miR-4488, hsa-miR-3158-3p, hsa-miR-151b, hsa-miR-3195, hsa-miR-1289, hsa-miR-20a-5p+hsa-miR-20b-5p, hsa-miR-32-5p, hsa-miR-525-3p
0 = Control, 1 = Disease, 2 = IgAN
Class	Control (0)	Disease (1)	IgAN (2)
Accuracy (95%CI)	0.7692 (0.4619-0.9496)	0.8462 (0.5455-0.9808)	0.7692 (0.4619-0.9496)
Sensitivity	0.33333	0.33333	0.8571
Specificity	0.9	1	0.6667
Positive predictive value	0.5	1	0.75
Negative predictive value	0.81818	0.83333	0.8
Prevalence	0.23077	0.2308	0.5385
Detection rate	0.07692	0.07692	0.4615
Detection prevalence	0.15385	0.07692	0.6154
AUC (95%CI)	0.733 (0.5-0.93)	1 (1-1)	0.88 (0.57-1)
Kappa	0.2642	0.4348	0.5301

¹Validation is presented in Supplementary Table 2, within the external cohort GSE64306.

miRNA: MicroRNA; IgAN: Immunoglobulin A nephropathy; CI: Confidence interval; AUC: Area under the receiver operating characteristic curve.