Potential diagnostic role of urinary exosomal microRNAs in immunoglobulin A nephropathy: A case-control study

doi:10.5527/wjn.119882

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World Journal of Nephrology

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2220-6124

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Control Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Nephrol. Sep 25, 2026; 15(3): 119882
Published online Sep 25, 2026. doi: 10.5527/wjn.119882

Table 8 Regulation status of 9 microRNAs within multiple comparisons performed using the nCounter microRNA expression assay

Type of differentiation	miRNAs	IgAN vs HC foldchange	IgAN vs HC P value	DC vs HC foldchange	DC vs HC P value	IgAN vs DC foldchange	IgAN vs DC P value
Differentiate IgAN and disease control	hsa-miR-1289	-1.19	0.05164487	-2.48	0.00001151	2.08	0.00001932
	hsa-miR-20a-5p+hsa-miR-20b-5p	-1.14	0.32179308	2.16	0.00004533	-2.46	0.00000026
	hsa-miR-32-5p	1.11	0.58471572	2.74	0.0002994	-2.48	0.0002138
	hsa-miR-525-3p	-1.13	0.46521613	2.05	0.00166705	-2.31	0.00012489
	hsa-miR-151b	-1.5	0.01793812	1.65	0.00405257	-2.48	0.00000064
	hsa-miR-4532	-2.06	0.00113097	1.17	0.68054599	-2.4	0.04225222
	hsa-miR-3195	-1.78	0.00082084	1.21	0.2488215	-2.14	0.00013383
Differentiate IgAN and healthy control	hsa-miR-4488	-2.65	0.02099009	-1.33	0.52975196	-2	0.05507494
Differentiate IgAN and healthy control	hsa-miR-3158-3p	-1.79	0.00653545	1.02	0.95068687	-1.82	0.07137911

miRNA: MicroRNA; IgAN: Immunoglobulin A nephropathy; HC: Healthy controls; DC: Disease controls.

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Citation: Shankar M, Moorthy M, Shetty A, Gurusiddaiah SC. Potential diagnostic role of urinary exosomal microRNAs in immunoglobulin A nephropathy: A case-control study. World J Nephrol 2026; 15(3): 119882
URL: https://www.wjgnet.com/2220-6124/full/v15/i3/119882.htm
DOI: https://dx.doi.org/10.5527/wjn.119882

Shankar M, Moorthy M, Shetty A, Gurusiddaiah SC. Potential diagnostic role of urinary exosomal microRNAs in immunoglobulin A nephropathy: A case-control study. World J Nephrol 2026; 15(3): 119882 [PMID: 42625985 DOI: 10.5527/wjn.119882]

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