Potential diagnostic role of urinary exosomal microRNAs in immunoglobulin A nephropathy: A case-control study

Table 6 Least absolute shrinkage and selection operator regression model selected 15 microRNAs that can differentiate immunoglobulin A nephropathy cases from healthy controls

miRNA	hsa.miR.769.3p	hsa.miR.671.3p	hsa.miR.641	hsa.miR.612	hsa.miR.548ar.5p	hsa.miR.548a5p	hsa.miR.513c.3p	hsa.miR.4488	hsa.miR.3158.3p	hsa.miR.30e5p	hsa.miR.297	hsa.miR.222.3p	hsa.miR.219b3p	hsa.miR.1269b	hsa.miR.1268a
Accuracy (95%CI)	0.818181818181818 (0.482244147639827-0.97716880170004)	0.727272727272727 (0.390257440427579-0.939782265827093)	0.818181818181818 (0.482244147639827-0.97716880170004)	0.818181818181818 (0.482244147639827-0.97716880170004)	0.727272727272727 (0.390257440427579-0.939782265827093)	0.727272727272727 (0.390257440427579-0.939782265827093)	0.727272727272727 (0.390257440427579-0.939782265827093)	0.818181818181818 (0.482244147639827-0.97716880170004)	0.818181818181818 (0.482244147639827-0.97716880170004)	0.727272727272727 (0.390257440427579-0.939782265827093)	0.727272727272727 (0.390257440427579-0.939782265827093)	0.727272727272727 (0.390257440427579-0.939782265827093)	0.818181818181818 (0.482244147639827-0.97716880170004)	0.909090909090909 (0.587220083011617-0.997701027786186)	0.818181818181818 (0.482244147639827-0.97716880170004)
Sensitivity	0	0.5	0	0	0	0	0	0.5	0.5	0	0.5	0	0	0.5	0
Specificity	1	0.7777777778	1	1	0.8888888889	0.8888888889	0.8888888889	0.8888888889	0.8888888889	0.8888888889	0.7777777778	0.8888888889	1	1	1
PPV	NA	0.3333333333	NA	NA	0	0	0	0.5	0.5	0	0.3333333333	0	NA	1	NA
NPV	0.8181818182	0.875	0.8181818182	0.8181818182	0.8	0.8	0.8	0.8888888889	0.8888888889	0.8	0.875	0.8	0.8181818182	0.9	0.8181818182
Prevalence	0.1818181818	0.1818181818	0.1818181818	0.1818181818	0.1818181818	0.1818181818	0.1818181818	0.1818181818	0.1818181818	0.1818181818	0.1818181818	0.1818181818	0.1818181818	0.1818181818	0.1818181818
Detection rate	0	0.09090909091	0	0	0	0	0	0.09090909091	0.09090909091	0	0.09090909091	0	0	0.09090909091	0
Detection prevalence	0	0.2727272727	0	0	0.09090909091	0.09090909091	0.09090909091	0.1818181818	0.1818181818	0.09090909091	0.2727272727	0.09090909091	0	0.09090909091	0
AUC (95%CI)	0.5 (0.5-0.5)	0.638888888888889 (0.128164113234834-1)	0.5 (0.5-0.5)	0.5 (0.5-0.5)	0.444444444444444 (0.335557556414441-0.553331332474447)	0.444444444444444 (0.335557556414441-0.553331332474447)	0.444444444444444 (0.335557556414441-0.553331332474447)	0.694444444444444 (0.192500691940002-1)	0.694444444444444 (0.192500691940002-1)	0.444444444444444 (0.335557556414441-0.553331332474447)	0.638888888888889 (0.128164113234834-1)	0.444444444444444 (0.335557556414441-0.553331332474447)	0.5 (0.5-0.5)	0.75 (0.260009003864987-1)	0.5 (0.5-0.5)
Kappa	0	0.2325581395	0	0	-0.1379310345	-0.1379310345	-0.1379310345	0.3888888889	0.3888888889	-0.1379310345	0.2325581395	-0.1379310345	0	0.6206896552	0

miRNA: MicroRNA; CI: Confidence interval; PPV: Positive predictive value; NPV: Negative predictive value; AUC: Area under the receiver operating characteristic curve.