Potential diagnostic role of urinary exosomal microRNAs in immunoglobulin A nephropathy: A case-control study

Table 5 microRNAs with area under the curve values > 0.75, with a high ability to differentiate immunoglobulin A nephropathy cases from disease controls

miRNAs	hsa.miR.769.5p	hsa.miR.3195	hsa.miR.4532	hsa.miR.151b
Category	IgAN vs Disease control
Accuracy (95%CI)	0.8 (0.44-0.97)	0.8 (0.44-0.97)	0.8 (0.44-0.97)	0.8 (0.44-0.97)
Sensitivity	0.5	0.5	0.5	0.5
Specificity	1	1	1	1
PPV	1	1	1	1
NPV	0.75	0.75	0.75	0.75
Prevalence	0.4	0.4	0.4	0.4
Detection rate	0.2	0.2	0.2	0.2
Detection prevalence	0.2	0.2	0.2	0.2
AUC (95%CI)	0.75 (0.46-1)	0.75 (0.46-1)	0.75 (0.46-1)	0.75 (0.46-1)
Kappa	0.55	0.55	0.55	0.55

miRNA: MicroRNA; CI: Confidence interval; PPV: Positive predictive value; NPV: Negative predictive value; AUC: Area under the receiver operating characteristic curve.