Potential diagnostic role of urinary exosomal microRNAs in immunoglobulin A nephropathy: A case-control study

Table 4 MicroRNAs with area under the curve values > 0.75 with a high ability to differentiate immunoglobulin A nephropathy cases from healthy controls

miRNAs	hsa.miR.409.5p	hsa.miR.101.3p	hsa.miR.4532	hsa.miR.654.3p
Category	IgAN vs healthy
Accuracy (95%CI)	0.90 (0.58-0.99)	0.90 (0.58-0.99)	1 (0.71-1)	0.63 (0.30-0.89)
Sensitivity	0.50	0.50	1.00	1.00
Specificity	1.00	1.00	1.00	0.56
PPV	1.00	1.00	1.00	0.33
NPV	0.90	0.90	1.00	1.00
Prevalence	0.18	0.18	0.18	0.18
Detection rate	0.09	0.09	0.18	0.18
Detection prevalence	0.09	0.09	0.18	0.55
AUC (95%CI)	0.75 (0.26-1)	0.75 (0.26-1)	1 (1-1)	0.77 (0.60-0.94)
Kappa	0.62	0.62	1.00	0.31

miRNA: MicroRNA; CI: Confidence interval; PPV: Positive predictive value; NPV: Negative predictive value; AUC: Area under the receiver operating characteristic curve.