Potential diagnostic role of urinary exosomal microRNAs in immunoglobulin A nephropathy: A case-control study

Table 10 A combination of 2 microRNAs could diagnose immunoglobulin A nephropathy cases with an area under the receiver operating characteristic curve > 0.8

Discovery cohort with 2 microRNAs	hsa-miR-4532, hsa-miR-548a-3p
0 = Healthy controls, 1 = Disease controls, 2 = IgA nephropathy cases
Class	Control (0)	Disease (1)	IgAN (2)
Accuracy (95%CI)	0.7692 (0.4619-0.9496)	0.8462 (0.5455-0.980)	0.8462 (0.5455-0.9808)
Sensitivity	0.6667	1	1
Specificity	1	1	0.8333
PPV	1	1	0.875
NPV	0.9091	1	1
Prevalence	0.2308	0.2308	0.5385
Detection rate	0.1538	0.2308	0.5385
Detection prevalence	0.1538	0.2308	0.6154
AUC (95%CI)	0.8333333 (0.5-1)	1 (1-1)	0.9047619 (0.741-1)
Kappa	0	0.4348	0.6905

miRNA: MicroRNA; IgAN: Immunoglobulin A nephropathy; CI: Confidence interval; PPV: Positive predictive value; NPV: Negative predictive value; AUC: Area under the receiver operating characteristic curve.