Integrated biomarkers and renal Doppler for early acute kidney injury diagnosis in hepatitis C virus cirrhosis

Figure 4 Survival analysis by acute kidney injury stage. A: Kaplan-Meier curves show a stepwise decrease in 30-day survival with increasing acute kidney injury stage (log-rank P < 0.001); B: Cox proportional hazards analysis, adjusted for Model for End-Stage Liver Disease includes serum sodium, infection status, and baseline neutrophil gelatinase-associated lipocalin, shows that acute kidney injury stage 2 and stage 3 are independently associated with mortality. Hazard ratio with 95%CI are shown. Stage 1 was not statistically significant (P = 0.14), while stage 2 (P = 0.008) and stage 3 (P < 0.001) were associated with significantly increased risk. AKI: Acute kidney injury.