Integrated biomarkers and renal Doppler for early acute kidney injury diagnosis in hepatitis C virus cirrhosis

Table 5 Adjusted hazard ratio for 30-day mortality by acute kidney injury stage (Cox model)

AKI stage	n	30-day mortality count	30-day mortality percentage	Cox P value	Comment	Hazard ratio (95%CI)
No AKI	42	1	2.4%	-	Baseline comparator	1.0 (reference)
Stage 1	28	2	7.1%	0.14	Mild injury, lower risk	2.8 (0.7-10.5)
Stage 2	25	5	20.0%	0.008	Intermediate severity	4.6 (1.5-13.8)
Stage 3	25	14	56.0%	< 0.001	High-risk group, dialysis/hepatorenal syndrome	9.3 (3.7-23.4)

Adjusted hazard ratio (95%CI) for 30-day mortality by acute kidney injury stage (Cox proportional hazards model adjusted for Model for End-Stage Liver Disease includes serum sodium, infection status, and baseline neutrophil gelatinase-associated lipocalin). AKI: Acute kidney injury.