Long-term outcomes following arteriovenous fistula ligation in kidney transplant recipients

Table 3 Multivariable analysis using time-varying events comparing outcomes in patients with post-transplant arteriovenous fistulae ligation vs non-ligation

	Univariate			Multivariate
	HR	95%CI	P value	HR	95%CI	P value
All-cause allograft survival
Age (years)	1.02	1.01-1.03	< 0.001	1.02	1.01-1.03	< 0.001
Diabetes	1.59	1.18-2.14	0.002	1.59	1.20-2.10	0.001
Time at ESKD	1.03	0.99-1.07	0.14
Living donor transplant	0.67	0.43-1.05	0.08
Delayed graft function	1.53	1.15-2.03	0.004	1.56	1.18-2.06	0.002
AVF ligation	0.73	0.52-1.03	0.072	0.72	0.51-1.01	0.059
Death with a functioning graft
Age (years)	1.08	1.06-1.11	< 0.001	1.08	1.05-1.10	< 0.001
Diabetes	1.89	1.18-3.04	0.009	2.02	1.30-3.16	0.002
Living donor transplant	0.43	0.17-1.08	0.072	0.39	0.15-0.96	0.042
AVF ligation	1.55	0.93-2.58	0.1
Death-censored allograft survival
Diabetes	1.41	0.98-2.04	0.067
Time at ESKD	1.03	0.99-1.08	0.14
Delayed graft function	1.71	1.20-2.44	0.003	0.85	1.31-2.59	< 0.001
AVF ligation	0.43	0.27-0.69	< 0.001	0.42	0.26-0.66	< 0.001

Variables investigated; age, gender, ethnicity, cause of end-stage kidney disease (ESKD), time at ESKD, type of donor, allograft number, induction, diabetes, delayed graft function, total human leukocyte antigen mismatch, sensitization, in addition to type of hemodialysis access. Variables are reported in the table if considered potentially significant (P < 0.15). These variables were included in multivariable model, with only statistically significant variables (P < 0.05) reported on adjusted analysis. AVF: Arteriovenous fistulae; CI: Confidence interval; ESKD: End-stage kidney disease; HR: Hazard ratio.