Protective effects of cerium oxide on ibuprofen-induced renal injury in rats with ureteral obstruction

doi:10.5527/wjn.v15.i1.114142

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World Journal of Nephrology

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2220-6124

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Nephrol. Mar 25, 2026; 15(1): 114142
Published online Mar 25, 2026. doi: 10.5527/wjn.v15.i1.114142

Table 4 Serum urea and creatinine levels in rats with ureteral obstruction (mean ± SEM)

	Group C (n = 6)	Group UO (n = 6)	Group UOI (n = 6)	Group UOCO (n = 6)	Group UOICO (n = 6)	¹P value
Urea (mg/dL)	25.75 ± 1.74	40.52 ± 3.18^a	45.56 ± 4.75^a	38.33 ± 2.04^a	43.50 ± 3.61^a	0.009
Kreatinin (mg/dL)	0.39 ± 0.05	0.76 ± 0.11^a	1.00 ± 0.16^a	0.79 ± 0.08^a	0.91 ± 0.12^a	0.008

¹P: Kruskal-Wallis test, significance set at P < 0.05.

^aP < 0.05 vs group C.

C: Control; UO: Unilateral ureteral obstruction; UOI: Unilateral ureteral obstruction + ibuprofen; UOCO: Unilateral ureteral obstruction + CeO₂; UOICO: Unilateral ureteral obstruction + ibuprofen + CeO₂.

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Citation: Toruk S, Babacan A, Arslan M, Şıvgın V, Sezen ŞC, Boyunağa H. Protective effects of cerium oxide on ibuprofen-induced renal injury in rats with ureteral obstruction. World J Nephrol 2026; 15(1): 114142
URL: https://www.wjgnet.com/2220-6124/full/v15/i1/114142.htm
DOI: https://dx.doi.org/10.5527/wjn.v15.i1.114142

Toruk S, Babacan A, Arslan M, Şıvgın V, Sezen ŞC, Boyunağa H. Protective effects of cerium oxide on ibuprofen-induced renal injury in rats with ureteral obstruction. World J Nephrol 2026; 15(1): 114142 [PMID: 41884232 DOI: 10.5527/wjn.v15.i1.114142]

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