Protective effects of cerium oxide on ibuprofen-induced renal injury in rats with ureteral obstruction

doi:10.5527/wjn.v15.i1.114142

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World Journal of Nephrology

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2220-6124

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Nephrol. Mar 25, 2026; 15(1): 114142
Published online Mar 25, 2026. doi: 10.5527/wjn.v15.i1.114142

Table 3 Oxidant parameters in the groups (mean ± SEM)

	Group C (n = 6)	Group UO (n = 6)	Group UOI (n = 6)	Group UOCO (n = 6)	Group UOICO (n = 6)	¹P value
MDA (nmol/mg protein)	3.28 ± 1.52	17.33 ± 2.30^a	25.75 ± 6.24^a	14.72 ± 2.03^a^,^b	17.48 ± 0.83^a	0.001
NO (IU/mg protein)	6.40 ± 1.76	19.74 ± 2.73^a	27.02 ± 3.90^a	18.76 ± 3.76^a^,^b	24.57 ± 3.68^a	< 0.0001

¹P: Kruskal-Wallis test, significance set at P < 0.05.

^aP < 0.05 vs group C.

^bP < 0.05 vs group UOI.

MDA: Malondialdehyde; NO: Nitric oxide; C: Control; UO: Unilateral ureteral obstruction; UOI: Unilateral ureteral obstruction + ibuprofen; UOCO: Unilateral ureteral obstruction + CeO₂; UOICO: Unilateral ureteral obstruction + ibuprofen + CeO₂.

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Citation: Toruk S, Babacan A, Arslan M, Şıvgın V, Sezen ŞC, Boyunağa H. Protective effects of cerium oxide on ibuprofen-induced renal injury in rats with ureteral obstruction. World J Nephrol 2026; 15(1): 114142
URL: https://www.wjgnet.com/2220-6124/full/v15/i1/114142.htm
DOI: https://dx.doi.org/10.5527/wjn.v15.i1.114142

Toruk S, Babacan A, Arslan M, Şıvgın V, Sezen ŞC, Boyunağa H. Protective effects of cerium oxide on ibuprofen-induced renal injury in rats with ureteral obstruction. World J Nephrol 2026; 15(1): 114142 [PMID: 41884232 DOI: 10.5527/wjn.v15.i1.114142]

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