Familial WT1-associated nephropathy - 46, XY Frasier syndrome and 46, XX steroid-resistant nephrotic syndrome in female siblings: A case report and review of literature

Figure 2 The figure presents the karyotype analysis of two siblings affected by primary steroid-resistant nephrotic syndrome. A: Chromosomal analysis report - elder daughter; B: Chromosomal analysis report - younger daughter. The elder sibling exhibits a male karyotype (46, XY), which supports the molecular diagnosis of Frasier syndrome associated with a WT1 gene mutation. In contrast, the younger sibling, also diagnosed with steroid-resistant nephrotic syndrome, shows a normal female karyotype (46, XX) with no detectable chromosomal abnormalities. SRN: Steroid-resistant nephrotic.