Role of antiphospholipid antibodies in kidney disease: Risk factors, immunopathogenesis, and diagnosis

doi:10.5527/wjn.v14.i4.110882

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World Journal of Nephrology

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2220-6124

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Nephrol. Dec 25, 2025; 14(4): 110882
Published online Dec 25, 2025. doi: 10.5527/wjn.v14.i4.110882

Table 1 Renal complications of antiphospholipid syndrome

Hypertension

Renal artery stenosis or thrombosis (unilateral or bilateral)

Renal vein thrombosis (unilateral or bilateral)

Ischemic nephropathy

APS nephropathy

Acute: Thrombotic microangiopathy

Chronic vaso-occlusive lesions: Cortical ischemia or infarction, interstitial fibrosis, tubular atrophy, specific intrarenal vasculopathy, arteriosclerosis, intimal hyperplasia, tubular thyroidization

Vascular access thrombosis in patients udergoing hemodialysis

Renal allograft

De novo or relapse of APSN of the allograft

Renal vein thrombosis

Renal artery thrombosis/stenosis

APS: Antiphospholipid syndrome; APSN: Antiphospholipid syndrome nephropathy.

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Citation: Abbas K, Naqvi R, Musharraf W, Mubarak M, Lal J. Role of antiphospholipid antibodies in kidney disease: Risk factors, immunopathogenesis, and diagnosis. World J Nephrol 2025; 14(4): 110882
URL: https://www.wjgnet.com/2220-6124/full/v14/i4/110882.htm
DOI: https://dx.doi.org/10.5527/wjn.v14.i4.110882

Abbas K, Naqvi R, Musharraf W, Mubarak M, Lal J. Role of antiphospholipid antibodies in kidney disease: Risk factors, immunopathogenesis, and diagnosis. World J Nephrol 2025; 14(4): 110882 [PMID: 41479829 DOI: 10.5527/wjn.v14.i4.110882]

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